Researcher synthesised demethoxycurcumin and bis-demethoxycurcumin, in HERr2 + cells and MCF-7, the phytochemicals were discovered to limit cancer cell proliferation, as shown by an IC50 value below 10 M ( in vitro IC 50 concentrations may not directly reflect clinically achievable plasma or tissue levels, and translational interpretation requires pharmacokinetic validation
These two molecules (pBDNF and mBDNF) participate in opposing functions: pBDNF binds to p75 receptor, initiating apoptosis, or shriveling of neurons, whereas, mBDNF has primary affinity for the TrkB receptor, which mediates neuroplasticity and resilience (223, 224)
Sewastjanow-Silva, M, Xiao, L, Nogueras Gonzalez, G, Wang, X, Hofstetter, WL, Swisher, SG , Mehran, RJ, Sepesi, B, Bhutani, M, Weston, B, Coronel, E, Waters, R, Rogers, JE, Smith, J, Lyons, L, Reilly, N, Yao, JC, Ajani, JA, Blum Murphy, M
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